Main Street Pizza and Cafe located in picturesque Irvine, Southern California, is serving some of the finest pizza and Italian dishes in the area. Whether you decide to take-out or have your food delivered, Main Street Pizza and Cafe offers fast and dependable service as well as delicious food. The portions are Gigantic and truly authentic. Right from the hand tossed dough and carefully chosen toppings to our specialty salads and pasta, our food will make you come back for more. What's more, our authentic Deidrich coffee and desserts will round off a satisfying dining experience for you. Main Street Pizza & Cafe also offers a dine-in area where you can come and sit and relax in our warm and welcoming atmosphere. No hype, no pretense, just delicious food in a homely setting.come and experience our unique recipes. We ARE OPEN FOR BREAKFAST, LUNCH, AND DINNER.